Table 4.
Acute treatment-associated toxicities for the four regimens.
| Adverse events | IMRT alone | CCRT | NAC+IMRT | NAC+CCRT | p | ||||
|---|---|---|---|---|---|---|---|---|---|
| 0-2 | 3-4 | 0-2 | 3-4 | 0-2 | 3-4 | 0-2 | 3-4 | ||
| Hematologic | |||||||||
| Leukocytopenia | 35 | 2 | 20 | 5 | 35 | 13 | 95 | 37 | 0.033 |
| Neutropenia | 34 | 3 | 18 | 7 | 33 | 15 | 92 | 40 | 0.048 |
| Anemia | 36 | 1 | 22 | 3 | 44 | 4 | 127 | 5 | 0.245 |
| Thrombocytopenia | 37 | 0 | 23 | 2 | 41 | 7 | 119 | 13 | 0.134 |
| Liver function | 37 | 0 | 24 | 1 | 45 | 3 | 125 | 7 | 0.517 |
| Renal function | 37 | 0 | 25 | 0 | 47 | 1 | 128 | 4 | 0.590 |
| Non-hematologic | |||||||||
| Mucositis | 36 | 1 | 20 | 5 | 45 | 3 | 105 | 27 | 0.012 |
| Dermatitis | 37 | 0 | 23 | 2 | 45 | 3 | 125 | 7 | 0.453 |
| Diarrhea | 37 | 0 | 25 | 0 | 46 | 2 | 128 | 4 | 0.511 |
| Nausea/vomiting | 37 | 0 | 24 | 1 | 42 | 6 | 118 | 14 | 0.127 |
Abbreviations: IMRT, intensity-modulated radiotherapy; CCRT, concurrent chemoradiotherapy; NAC, neoadjuvant chemotherapy.