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. 2018 Jun 11;9:2265. doi: 10.1038/s41467-018-04711-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Altering the D2S/D2L ratio in favor of D2S improves executive functions exclusively in mice with genetic reduction of dysbindin-1. a Dys+/−D2L+/− double mutant mice (magenta bar), single Dys+/− (blue bar), single D2L+/− (red bar) and wild-type (white bar) littermates were generated by mating double heterozygous males with naive C57 female mice. b D2S/D2L ratio was increased in the mPFC of D2L single mutant (Dys+/+D2L+/−) and Dys+/−D2L+/− double mutant mice compared to wild-type controls (n = 6–10 each group; one-way ANOVA, F_{(3, 29)} = 10.44, p < 0.0005). c Dys+/-D2L+/- double mutant mice needed less trials to solve the EDS compared to Dys+/− mice (unpaired t-test, t = 3.13, df = 13, p < 0.05 n = 8–12 each group. One-way ANOVA, F_{(3, 33)} = 2.30, p = 0.09). d Dys+/-D2L+/- double mutant mice completed the EDS in less time compared to Dys+/− single mutant mice and wild-type controls (one-way ANOVA, F_{(3, 36)} = 3.64, p < 0.05; n = 8–12 each group). Error bars represent S.E.M. *p < 0.05, **p < 0.005