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. 2018 Jun 5;11:181. doi: 10.3389/fnmol.2018.00181

Figure 1.

Figure 1

Depigmentation and profound sensorineural hearing loss in the SRY-box 10 (SOX10) mutation miniature porcine model. (A) Gross image of a WT bama miniature pig and a mutation-type albino pig. (B) The results of the auditory brainstem response (ABR) tests showed profound hearing loss in the SOX10 mutation pigs. The ABR tests showed an absence of recognizable ABR waveforms up to a 110 dB sound pressure level (SPL) with a stimulus range from 4 kHz to 32 kHz in the SOX10 mutation minipigs. The WT minipigs had ABR thresholds at 30–40 dB SPL (WT, wild-type; MT, mutation type; SOX10 mutation-type).