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. 2018 Jun 5;11:181. doi: 10.3389/fnmol.2018.00181

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Copyright © 2018 Hao, Li, Chen, Jiang, Ji, Sun, Wei, Guo and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene ontology (GO) and KEGG pathway analyses of the down-regulated genes. Based on GO biological processes (BP), the down-regulated DEGs significantly enriched the xanthine catabolic process, forebrain anterior/posterior pattern specification, and retinal development in the camera-type eye. Per the cellular components (CC) analysis, the down-regulated DEGs significantly enriched the integral membrane component, integral plasma membrane component and the newly growing cell tip. Based on the molecular function (MF), the down-regulated DEGs significantly enriched iron ion binding, oxidoreductase activity (acting on paired donors), and ATPase activity (coupled to transmembrane movement). The most significantly enriched pathways associated with the down-regulated DEGs were the inflammatory mediator regulation of TRP channels, arachidonic acid metabolism and salivary secretion.