Table 2.
Overview of genomic signature datasets.
| Cancer Type (TCGA-defined) | Cancer gene census | ||||
|---|---|---|---|---|---|
| Abbreviation | Description | Number of cell lines | Number of genes | Number of mutation positions | |
| Datasets included in the final model | |||||
| 1 | ALL | Acute lymphoblastic leukemia | 26 | 441 | 2,104 |
| 2 | BLCA | Bladder Urothelial Carcinoma | 19 | 240 | 484 |
| 3 | BRCA | Breast invasive carcinoma | 51 | 372 | 1,103 |
| 4 | CESC | Cervical squamous cell carcinoma and endocervical adenocarcinoma | 14 | 219 | 406 |
| 5 | COAD_READ | Colon adenocarcinoma and Rectum adenocarcinoma | 51 | 478 | 5,582 |
| 6 | DLBC | Lymphoid Neoplasm Diffuse Large B-cell Lymphoma | 35 | 325 | 933 |
| 7 | ESCA | Esophageal carcinoma | 35 | 334 | 880 |
| 8 | GBM | Glioblastoma multiforme | 36 | 247 | 533 |
| 9 | HNSC | Head and Neck squamous cell carcinoma | 42 | 299 | 729 |
| 10 | KIRC | Kidney renal clear cell carcinoma | 32 | 233 | 490 |
| 11 | LAML | Acute Myeloid Leukemia | 28 | 326 | 816 |
| 12 | LCML | Chronic Myelogenous Leukemia | 10 | 214 | 346 |
| 13 | LGG | Brain Lower Grade Glioma | 17 | 176 | 285 |
| 14 | LIHC | Liver hepatocellular carcinoma | 17 | 181 | 315 |
| 15 | LUAD | Lung adenocarcinoma | 63 | 389 | 1,689 |
| 16 | LUSC | Lung squamous cell carcinoma | 15 | 188 | 324 |
| 17 | MESO | Mesothelioma | 21 | 170 | 286 |
| 18 | MM | Multiple Myeloma | 18 | 205 | 351 |
| 19 | NB | Neuroblastoma | 32 | 267 | 512 |
| 20 | OV | Ovarian serous cystadenocarcinoma | 34 | 336 | 917 |
| 21 | PAAD | Pancreatic adenocarcinoma | 30 | 230 | 448 |
| 22 | SCLC | Small Cell Lung Cancer | 66 | 405 | 1,598 |
| 23 | SKCM | Skin Cutaneous Melanoma | 55 | 391 | 1,610 |
| 24 | STAD | Stomach adenocarcinoma | 24 | 336 | 910 |
| 25 | THCA | Thyroid carcinoma | 16 | 201 | 310 |
| Subtotal | 787 | 567 | 28,328 | ||
| Datasets excluded from the final model | |||||
| 1 | ACC | Adrenocortical carcinoma | 1 | 20 | 20 |
| 2 | CLL | Chronic Lymphocytic Leukemia | 3 | 29 | 33 |
| 3 | MB | Medulloblastoma | 4 | 47 | 52 |
| 4 | PRAD | Prostate adenocarcinoma | 6 | 259 | 454 |
| 5 | UCEC | Uterine Corpus Endometrial Carcinoma | 9 | 377 | 1,168 |