Table 2.
List of the differentially expressed metabolites involved in amino acid metabolism during the acute and chronic phases of Toxoplasma gondii infection.
| Metabolites | FC | q-value | VIP | CV | Metabolic pathways |
|---|---|---|---|---|---|
| ACUTELY INFECTED VS. CONTROL | |||||
| L-Thyroxine | 0.23 | 4.73e-03 | 1.19 | ↓ | Tyrosine metabolism |
| 3-Methoxy-4-hydroxyphenylacetaldehyde | 0.51 | 2.83e-02 | 1.08 | ↓ | |
| gamma-Glutamyl-gamma-aminobutyraldehyde | 2.59 | 4.45e-03 | 1.80 | ↑ | Arginine and proline metabolism |
| Nopaline | 1.84 | 6.92e-03 | 1.21 | ↑ | |
| Indole-3-ethanol | 2.17 | 5.45e-03 | 1.38 | ↑ | Tryptophan metabolism |
| Taurocholate | 0.12 | 3.70e-02 | 1.20 | ↓ | Taurine and hypotaurine metabolism |
| Glutathionylspermidine | 1.77 | 8.84e-03 | 1.21 | ↑ | Glutathione metabolism |
| Trypanothione disulfide | 2.16 | 8.94e-03 | 1.15 | ↑ | |
| Trypanothione | 9.45 | 1.81e-03 | 3.28 | ↑ | |
| CHRONICALLY INFECTED VS. CONTROL | |||||
| L-Thyroxine | 0.12 | 5.00e-04 | 1.71 | ↓ | Tyrosine metabolism |
| 3-Methoxy-4-hydroxyphenylacetaldehyde | 0.50 | 2.58e-02 | 1.19 | ↓ | |
| L-Cystathionine | 0.51 | 2.08e-02 | 1.21 | ↓ | Glycine, serine and threonine metabolism; Cysteine and methionine metabolism |
| N-Formyl-L-aspartate | 0.65 | 3.73e-04 | 1.03 | ↓ | Histidine metabolism |
| Glutathionylspermidine | 1.58 | 3.39e-02 | 1.01 | ↑ | Glutathione metabolism |
| Trypanothione disulfide | 2.66 | 3.34e-03 | 1.56 | ↑ | |
| Trypanothione | 6.21 | 5.32e-03 | 2.95 | ↑ | |
FC, Fold change; q-value, adjusted p value calculated by the two-tailed Wilcoxon rank-sum tests after false discovery rate correction; VIP, variable importance in projection; CV, Content variance. A single arrow (↑/↓) indicates increased or decreased values compared to the control group.