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. 2018 Jun 5;9:566. doi: 10.3389/fphar.2018.00566

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Copyright © 2018 Sobeh, Mahmoud, Petruk, Rezq, Ashour, Youssef, El-Shazly, Monti, Abdel-Naim and Wink.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hepatoprotective potential of S. aqueum leaf extract on liver pathology after CCl₄ treatment in rats, stained by hematoxylin-eosin. (A) Liver of normal control rat with normal hepatic architecture, hepatocyte structure and central vein. (B) Liver afterCCl₄ intoxication with severe changes including dilated central vein with central hepatocellular necrosis (arrows) and congested portal triad. (C) Liver of a rat treated with silymarin prior to CCl₄administration; only scattered cytoplasmic vacuolization (arrows) were detected. (D) Liver of a rat treated with the extract (200 mg/kg, b.w.) prior to CCl₄ injection showing scattered cytoplasmic vacuolization (arrows).