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. 2018 Jun 5;9:1158. doi: 10.3389/fmicb.2018.01158

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Copyright © 2018 Hoogendoorn, Barra, Waalwijk, Dickschat, van der Lee and Medema.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The fusarubin BGC as visualized by (A) the sequence similarity network. Colors correspond to the same genomes as in Figure 2. A smaller width of the connecting lines indicates a larger raw distance between two nodes. (B) Phylogeny based on the polyketide synthase (PKS) gene shows a large distance between the PKS of F. pseudograminearum_2 and the other PKSs indicating that its BGC is indeed distantly related and probably not involved in fusarubin production. Bootstrap consensus percentages are shown at nodes in the tree. (C) Chemical structure of fusarubin (D) Multigeneblast result. The next most similar BGC immediately outside the GCF is indicated at the bottom. Genes with annotations in red are not known to be associated with fusarubin production.