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. 2018 Jun 5;9:1198. doi: 10.3389/fmicb.2018.01198

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Copyright © 2018 Duan, Lu, Garcia, Yañez, Nandre, Sack and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mouse serum antibody in vitro neutralization activities against STa and CT enterotoxicity, measured with T-84 cells and a cGMP or a cAMP EIA kit (Enzo Life Sciences). (A) The serum samples of the mice IP immunized with tag-less toxoid fusion 3xSTa_N12S-mnLT_R192G/L211A (9471) or 6xHis-tagged 3xSTa_N12S-mnLT_R192G/L211A (9331) prevented STa toxin from elevating intracellular cyclic GMP in T-84 cells, whereas serum from the control mice (without injection) did not prevent STa from stimulating cGMP in T-84 cells. (B) The serum samples from the mice IP immunized with tag-less 3xSTa_N12S-mnLT_R192G/L211A (9471) or 6xHis-tagged 3xSTa_N12S-mnLT_R192G/L211A (9331) prevented CT toxin from elevating intracellular cyclic AMP in T-84 cells.