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. 2018 Jun 5;9:592. doi: 10.3389/fphar.2018.00592

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Copyright © 2018 Wang, Gu, Eijkelkamp, Heijnen and Kavelaars.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of GRK2 overexpression on GDNF-induced hyperalgesic priming. GDNF-induced hyperalgesia and effect of two intraplantar injections (arrows) of HSV-GRK2-GFP or HSV-GFP (1.4 × 10⁷ pfu/mL, 2.5 μL/paw). Two days after the last HSV inoculation, the GDNF-primed mice were treated with PGE₂ (100 ng/paw). The 50% paw withdrawal thresholds were monitored over time. Data are expressed as mean ± SEM. n = 6/group. F = 27.81; DFn = 1, DFd = 230. Bonferroni’s multiple comparisons test: ^∗∗P < 0.01, ^∗∗∗P < 0.001.