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. 2018 Jun 5;9:694. doi: 10.3389/fphys.2018.00694

FIGURE 1.

FIGURE 1

Effect of 30 days of chronic intermittent hypoxia (CIH30) on guinea pig breathing pattern. (A) Sample plethysmography recordings of one control (CIH0) and one CIH30 guinea pig breathing air (21% O2), or 10% O2, 7% O2 and 5% CO2 acute tests. In (B), Respiratory frequency (RF) expressed as breaths per minute (bpm) and in (C), Tidal volume (TV) expressed as mL/kg from CIH0 and CIH30 guinea pigs in response to acute hypoxia (12% O2, 10% O2, 7% O2) and hypercapnia (5% CO2) tests. #p < 0.05; ##p < 0.01; ###p < 0.001 vs. basal CIH0; +++p < 0.001 vs. basal CIH30. Data are mean ± SEM; n = 16. Two-way ANOVA with Tukey’s multiple comparison test for analysis between CIH0 and CIH30, and one-way ANOVA with Dunnett’s multiple comparison test for analysis intra group (vs. basal).