Table 1.
Arterial blood gasometry data, hematocrit and erythropoietin measurements in control and CIH guinea pigs breathing normoxia (21% O2) or acute hypoxia (10% O2).
| Guinea pigs | C | CIH | ||
|---|---|---|---|---|
| 21% O2 | 10% O2 | 21% O2 | 10% O2 | |
| pO2(mmHg) | 65 ± 6 | 29 ± 3+++ | 64 ± 6 | 22 ± 2+++ |
| pCO2(mmHg) | 36 ± 2 | 32 ± 1 | 38 ± 3 | 36 ± 2 |
| PH | 7.49 ± 0.02 | 7.52 ± 0.01 | 7.47 ± 0.02 | 7.49 ± 0.01 |
| HCO3- (mM) | 27 ± 1 | 26 ± 1 | 27 ± 1 | 27 ± 1 |
| SaO2 (%) | 91 ± 2 | 62 ± 5+++ | 90 ± 3 | 44 ± 6+++ ∗ |
| Ht (%) | 41.5 ± 0.8 | 41.4 ± 0.8 | ||
| EPO (mU/mL) | 141 ± 17 | 214 ± 52∗ | ||
+++p < 0.001 10% O2 vs. 21% O2 in each group; ∗p < 0.05 CIH vs. C. Data are mean ± SEM (n = 8). Two-Way ANOVA with Sidak’s multiple comparison test.