Table 2.
Gene expression levels in fold change values determined by microarray analysis for fibrosis formation.
| ID | Name | Trauma vs. Control | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Normal | Obese | ||||||||||
| 1 h | 6 h | 24 h | 3 days | 8 days | 1 h | 6 h | 24 h | 3 days | 8 days | ||
| PRO-FIBROTIC | |||||||||||
| 11475 | Acta2 | 1.25 | −1.14 | 1.08 | 3.14 | 1.16 | −1.05 | 1.13 | 1.06 | −1.15 | 1.15 |
| 11606 | Agt | 1.06 | 1.15 | 1.27 | −1.92 | −1.33 | 1.58 | 1.10 | −1.11 | −1.08 | −1.23 |
| 20302 | Ccl3 | 2.46 | 7.16 | 1.24 | 5.45 | 1.18 | 3.93 | 7.50 | 1.40 | 2.00 | 1.13 |
| 14219 | Ctgf | 2.35 | 2.35 | −1.96 | 3.70 | 1.36 | 1.91 | 1.92 | −1.15 | −1.15 | −1.09 |
| ANTI-FIBROTIC | |||||||||||
| 16154 | Il10ra | −1.15 | 1.12 | 1.07 | 3.21 | 1.46 | 1.19 | 1.02 | 1.16 | 1.39 | 1.06 |
| 16155 | Il10rb | 1.28 | 1.03 | −1.16 | 5.45 | 1.75 | 1.10 | 1.15 | 1.11 | 1.89 | 1.25 |
| 16164 | Il13ra1 | 1.37 | 1.89 | 1.06 | 4.96 | 1.66 | 1.22 | 2.56 | 1.12 | 1.10 | 1.25 |
| COLLAGEN COMPONENTS | |||||||||||
| 12816 | Col12a1 | 1.69 | 1.43 | −1.97 | 4.67 | 2.47 | 1.27 | 1.17 | −1.37 | 1.25 | 1.08 |
| 12818 | Col14a1 | 1.44 | 1.14 | −1.02 | 2.30 | 2.88 | −1.34 | −1.03 | 1.18 | 1.31 | 1.53 |
| 12842 | Col1a1 | 1.54 | 1.35 | −1.02 | 5.74 | 4.43 | −1.03 | −1.07 | 1.20 | 2.96 | 1.23 |
| 12843 | Col1a2 | 1.49 | 1.29 | −1.20 | 4.55 | 3.24 | −1.06 | −1.04 | 1.18 | 2.32 | 1.13 |
| 12825 | Col3a1 | 1.53 | 1.14 | 1.66 | 4.59 | 3.71 | −1.26 | 1.04 | 1.38 | 2.65 | 1.48 |
| 12832 | Col5a2 | 1.26 | 1.15 | 1.11 | 3.36 | 2.50 | 1.05 | 1.06 | 1.12 | 1.88 | 1.18 |
| 12833 | Col6a1 | 1.30 | 1.08 | 1.11 | 2.22 | 1.86 | −1.11 | −1.03 | 1.24 | 1.53 | 1.14 |
| 12835 | Col6a3 | 1.17 | 1.25 | 1.40 | 2.31 | 2.18 | −1.26 | 1.08 | 1.42 | 1.71 | 1.21 |
| 12837 | Col8a1 | 1.14 | −1.03 | −1.17 | 4.60 | 1.99 | 1.06 | 1.14 | −1.21 | 1.23 | −1.01 |
| 14268 | Fn1 | 1.82 | 1.35 | 1.00 | 6.07 | 3.39 | −1.11 | 1.16 | 1.04 | 1.18 | 1.51 |
| REMODELING ENZYMES | |||||||||||
| 16948 | Lox | 2.53 | 3.12 | −1.14 | 12.02 | 2.36 | 1.34 | 2.17 | 2.06 | 3.64 | 1.22 |
| 268977 | Ltbp1 | 1.14 | 1.18 | −1.06 | 2.27 | 1.62 | 1.01 | −1.01 | 1.06 | 1.04 | 1.10 |
| 17387 | Mmp14 | 1.32 | 1.37 | 1.03 | 3.40 | 2.80 | 1.11 | 1.34 | 1.00 | 1.77 | 1.31 |
| 17390 | Mmp2 | 1.19 | 1.03 | −1.23 | 1.77 | 2.63 | −1.07 | −1.17 | −1.00 | 1.25 | 1.23 |
| 17392 | Mmp3 | 1.16 | 2.97 | 1.92 | 1.15 | 1.28 | −1.14 | 1.94 | 2.19 | 2.28 | 1.14 |
| 18791 | Plat | 1.23 | 1.19 | −1.32 | 2.59 | 1.47 | 1.17 | 1.29 | 1.01 | 1.06 | 1.29 |
| 18792 | Plau | 1.13 | 1.15 | −1.00 | 2.77 | 1.16 | 1.09 | 1.32 | 1.06 | 1.50 | 1.02 |
| 18787 | Serpine1 | 4.44 | 3.18 | 1.18 | 9.62 | 1.19 | 3.69 | 3.30 | 1.19 | 1.74 | 1.06 |
| 20720 | Serpine2 | −1.14 | 1.01 | −1.03 | −1.94 | −1.75 | 1.05 | −1.05 | −1.13 | −1.15 | −1.07 |
| 21857 | Timp1 | 1.14 | 4.14 | 1.43 | 19.05 | 1.91 | 1.74 | 3.79 | 1.52 | 2.66 | 1.09 |
| 21858 | Timp2 | 1.17 | 1.05 | −1.34 | 2.04 | 1.61 | −1.06 | −1.09 | 1.03 | 1.09 | 1.05 |
| OTHER REGULATORY FACTORS AND MARKERS | |||||||||||
| 12111 | Bgn | 1.16 | −1.01 | −1.14 | 4.81 | 2.31 | 1.05 | −1.03 | −1.06 | 2.07 | 1.07 |
| 12153 | Bmp1 | 1.17 | 1.06 | 1.01 | 2.23 | 1.71 | 1.05 | −1.00 | −1.01 | 1.25 | 1.15 |
| 18034 | Nfkb2 | 1.15 | 1.34 | 1.08 | 2.10 | 1.80 | 1.20 | 1.17 | 1.03 | 1.13 | 1.05 |
| 18542 | Pcolce | −1.06 | 1.11 | 1.26 | 2.56 | 1.60 | −1.20 | −1.11 | 1.45 | 1.37 | −1.03 |
| 21425 | Tfeb | −1.14 | 1.01 | 1.24 | −1.53 | −1.37 | −1.00 | −1.13 | 1.04 | 1.28 | −1.05 |
| 21803 | Tgfb1 | 1.19 | 1.52 | 1.30 | 5.10 | 3.23 | 1.18 | 1.40 | 1.26 | 1.86 | 1.11 |
| 21813 | Tgfbr2 | 1.22 | 1.29 | −1.08 | 2.25 | 1.66 | 1.01 | 1.23 | 1.05 | 1.22 | 1.02 |
| 21838 | Thy1 | 1.10 | 1.25 | −1.01 | 3.98 | 2.11 | 1.02 | −1.05 | 1.01 | 1.40 | 1.29 |
| 21897 | Tlr1 | 1.02 | 1.15 | 1.28 | 2.58 | 1.24 | −1.07 | 1.13 | 1.11 | 1.54 | 1.11 |
| 279572 | Tlr13 | 1.36 | 1.89 | 1.20 | 10.16 | 1.55 | 1.33 | 2.49 | 1.70 | 3.03 | 1.14 |
| 24088 | Tlr2 | 1.74 | 1.12 | 1.06 | 2.05 | 1.32 | 1.49 | 1.33 | 1.05 | 1.22 | 1.06 |
| 21898 | Tlr4 | 1.74 | 1.61 | −1.40 | 3.70 | 2.20 | 1.16 | 1.32 | −1.03 | 1.48 | 1.12 |
| 170743 | Tlr7 | 1.31 | 1.22 | 1.12 | 10.26 | 1.82 | 1.06 | 1.07 | 1.54 | 2.60 | 1.07 |
| 170744 | Tlr8 | 1.27 | 1.61 | 1.28 | 5.90 | 1.54 | −1.22 | 1.26 | 1.16 | 2.60 | 1.18 |
| 81897 | Tlr9 | 1.15 | 1.15 | 1.12 | 3.32 | 1.31 | −1.11 | 1.12 | 1.26 | 1.63 | 1.05 |
Red = significantly upregulated, green = significantly downregulated. Significance level is p ≤ 0.05. Log2 values were converted to fold change, and subsequently if value < 1 inverted to get negative values, thus baseline = ±1. Values with at least one significant value ≥ ± 1.5 are shown. For corresponding significance levels, see Supplementary Table 2.