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Reagents and conditions: General synthetic approach to quinazolinones 1, 2, 4–11, and 14: (a) neat thiourea at 180 °C, 3 h; (b) 2-bromoacetic acid, triethylamine, DMF, 80 °C, 12 h; (c) primary and/or secondary amine 31, EDC·HCl, HOAT, N,N-diisopropylethylamine, DMF/ACN (1:1), room temperature, 12 h or primary and/or secondary amine 31, HATU, N,N-diisopropylethylamine, DCM, room temperature, 12 h.
