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Minimum inhibitory concentration (MIC) is the minimum concentration required to inhibit >99% growth of M. tuberculosis in liquid culture. Isoniazid was included as an internal control reference compound (MIC of 0.2 ± 0.1 μM).
Intrinsic clearance (Cli) using CD1 mouse liver microsomes.
Kinetic aqueous solubility was measured using laser nephelometry of compounds in 2.5% DMSO.
