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. 2018 Apr 30;8(11):3087–3098. doi: 10.7150/thno.24426

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5-HT₆R-mediated RhoA GTPase signaling increases bone resorption in mice. (A) Scheme for the assessment of the LPS bone resorption mouse model. (B-C) μCT images are shown (B), and bone volume (BV) per tissue volume (TV) of calvarias (right) were analyzed and plotted as individual points (C). (D-F) Calvarias were coronally sectioned in regions a and b indicated by the arrow (left) and analyzed using H&E staining (right) (D). The differences of bone cavity (E) and the number of osteoclasts (OCs) (F) were analyzed. Scale bar: 100 μm. Rho: Rhosin. *, p < 0.05 compared to LPS. #, p < 0.05 compared LPS+ST1936. Data shown represent mean ± SEM.