Figure 6.
(A) Structure of polymer-drug conjugate. (B) Schematic illustration of the pH-sensitive cluster nanobomb at neutral pH and the disintegration into small particles at tumor due to its acidic pH. (C) Schematic illustration of cluster nanobomb for in vivo drug delivery in the poorly permeable pancreatic tumor model. (I) large superstructure for prolonged blood circulation, (II) targeted tumor accumulation via EPR, (III) pH-responsive disintegration into small particles for deep tumor parenchyma penetration. Hydrodynamic diameter and TEM of polymer-drug conjugate at (D) pH 7.4 and (E) pH 6.7. (F) pH-dependent size change detected by DLS. Reproduced with permission from 90. Copyright 2016, American Chemical Society.