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. 2018 Apr 30;8(11):3074–3086. doi: 10.7150/thno.24281

Figure 5.

Figure 5

Monitoring of PNI by MRI scans in vivo. PANC-1 cells labeled with IONP, PANC-1IONP, exhibited low signals upon MRI. Right sciatic nerves were injected with PANC-1 IONP (blue arrow) and left sciatic nerves were injected with PANC-1 IONP + TAMs (yellow arrow). From day 0 to day 7, no apparent PNI was observed in either sciatic nerve. On day 10, a low-signal area on the left sciatic nerve became enlarged and demonstrated thickened sciatic nerves, indicative of PNI. On day 17, both sciatic nerves exhibited PNI, but the left side was more apparent than the right side. On day 20, left hind limb paralysis was observed and tumor formation was detected on the left side by MRI and surgical images. The right hind limb did not exhibit paralysis and no tumor formation was detected. On day 24, left hind limb paralysis was more severe. MRI clearly showed cancer cell invasion along nerves from the left sciatic nerve injection area (yellow arrow) toward the spinal cord (white arrow).