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H&E staining of sciatic nerves at individual time points was consistent with MRI. Cancer cells were restricted to the injection area under the epineurium (black arrow) without contacting a nerve bundle (yellow arrow) on days 0, 3, and 7. From day 10, cancer cells infiltrated into the left sciatic nerve tract and progressed thereafter. Cancer cells infiltrated into the right sciatic nerve tract on day 17 and the progression was much less severe than that on the left side.
