Table 2.

Comparison of the frequency of mucocutaneous side effects of isotretinoin between case and control groups.

	Isotretinoin group (%)	Isotretinoin + omega-3 group (%)	P value
Dry lips
Baseline	0	0
Week 4	78.7	58	0.030∗
Week 8	64.8	50	0.041∗
Week 12	44.4	26	0.044∗
Week 16	25.6	14	0.130
Dry nose
Baseline	0	0
Week 4	33.3	12	0.010∗
Week 8	24.1	10	0.003∗
Week 12	14	2	0.020∗
Week 16	11.1	0	0.001∗
Dry skin
Baseline	0	0
Week 4	40.7	16	0.003∗
Week 8	22.2	10	0.021∗
Week 12	18.5	8	0.002∗
Week 16	11.1	2	0.013∗
Dry eyes
Baseline	0	0
Week 4	13	4	0.046∗
Week 8	9.3	6	0.533
Week 12	3.7	0	0.169
Week 16	0	0	1.00

^∗ P values less than 0.05 were considered significant.