Figure 2.

(a) Concentration dependency. Concentration-dependent change in resting membrane potential in human neutrophils after incubation with C5a demonstrating a depolarization in a dose-dependent manner (n = 11; 45; 6). (b) Time dependency. Time-dependent change of resting membrane potential of human PMN after stimulation with C5a 100 ng/ml (straight black line) and C5a 1000 ng/ml (gray dotted line), n = 3–45. All significance indicators refer to C5a 100 ng/ml. ^∗ p < 0.05, ^∗∗ p < 0.01, and ^∗∗∗ p < 0.001.