Table 3.
Rates for MACE and death based on prevalence of cardiovascular risk factors
| Risk Factors | 0 factor | Any factor | 1 factor | 2 factors | ≥ 3 factors |
|---|---|---|---|---|---|
| Baseline ESA Nonusers | |||||
| (N = 2226) | (N = 29,973) | (N = 10,537) | (N = 9334) | (N = 10,102) | |
| MACE | |||||
| Event n | 92 | 6205 | 1192 | 1679 | 3334 |
| Pt-year | 5181 | 66,036 | 24,811 | 21,209 | 20,016 |
| Mean follow-up years | 2.33 | 2.20 | 2.35 | 2.27 | 1.98 |
| Rate per 100 pt-year (95% CI)a | 1.78 (1.45, 2.18) | 9.40 (9.17, 9.63) | 4.80 (4.54, 5.08) | 7.92 (7.55, 8.30) | 16.66 (16.10, 17.23) |
| Death | |||||
| Event n | 19 | 2880 | 511 | 781 | 1588 |
| Pt-year | 5277 | 71,519 | 25,855 | 22,590 | 23,073 |
| Mean follow-up years | 2.37 | 2.39 | 2.45 | 2.42 | 2.28 |
| Rate per 100 pt-year (95% CI)a | 0.36 (0.23, 0.56) | 4.03 (3.88, 4.18) | 1.98 (1.81, 2.16) | 3.46 (3.22, 3.71) | 6.88 (6.55, 7.23) |
| Baseline ESA Users | |||||
| (N = 1) | (N = 108) | (N = 17) | (N = 29) | (N = 62) | |
| MACE | |||||
| Event n | 0 | 36 | 1 | 6 | 29 |
| Pt-year | 1.1 | 182 | 36 | 58 | 88 |
| Mean follow-up years | 1.05 | 1.69 | 2.12 | 2.00 | 1.42 |
| Rate per 100 pt-year (95% CI)a | NA | 19.75 (14.25, 27.38) | 2.78 (0.39, 19.70) | 10.35 (4.65, 23.03) | 32.87 (22.84, 47.30) |
| Death | |||||
| Event n | 0 | 26 | 1 | 2 | 23 |
| Pt-year | 1.1 | 201 | 36 | 60 | 106 |
| Mean follow-up years | 1.05 | 1.87 | 2.12 | 2.06 | 1.70 |
| Rate per 100 pt-year (95% CI)a | NA | 12.91 (8.79, 18.96) | 2.78 (0.39, 19.70) | 3.34 (0.84, 13.37) | 21.78 (14.47, 32.78) |
| ESA Naives | |||||
| (N = 5) | (N = 261) | (N = 30) | (N = 68) | (N = 163) | |
| MACE | |||||
| Event n | 0 | 77 | 3 | 19 | 55 |
| Pt-year | 3.9 | 294 | 39 | 84 | 171 |
| Mean follow-up years | 0.78 | 1.13 | 1.29 | 1.24 | 1.05 |
| Rate per 100 pt-year (95% CI)a | NA | 26.16 (20.93, 32.71) | 7.73 (2.49, 23.97) | 22.52 (14.36, 35.30) | 32.14 (24.67, 41.86) |
| Death | |||||
| Event n | 0 | 42 | 2 | 9 | 31 |
| Pt-year | 3.9 | 333 | 30 | 97 | 197 |
| Mean follow-up years | 0.78 | 1.27 | 1.30 | 1.43 | 1.20 |
| Rate per 100 pt-year (95% CI)a | NA | 12.62 (9.33, 17.08) | 5.11 (1.28, 20.45) | 9.28 (4.83, 17.84) | 15.76 (11.08, 22.41) |
Abbreviations: CI confidence interval, eGFR estimated glomerular filtration rate, ESA erythropoiesis-stimulating agent, Hb hemoglobin, MACE major adverse cardiovascular events, n event count, pt patient, yr year. aEvent rates 95% confidence intervals are based on exact Poisson estimates. In the case that an exact Poisson regression failed, normal approximation was used