Subject area	Biology
More specific subject area	Clinical chemistry, Biomarker analysis, proteoform profiling
Type of data	Tables, figures
How data was acquired	Ultimate nano-RSLC system (Thermo Fischer Scientific Waltham, USA) coupled to Impact II™ benchtop UHR-Q-ToF (Bruker Daltonik, Bremen, Germany) through a CaptiveSpray nanoBooster™ source (Bruker Datonik, Bremen, Germany)
Data format	Analyzed and processed data
Experimental factors	CSF was collected in polypropylene tubes under standardized conditions between 9 a.m. and 1 p.m. in order to minimize the effects of diurnal variations. Each CSF sample was sent within 4 h of being collected to the local laboratory, where it was centrifuged at 1000 × g for 10 min at a temperature of 4 °C. CSF was then aliquoted into 1.5 ml polypropylene tubes and stored at −80 °C.
Experimental features	500 µL of human CSF mixed with twenty-five microliters of 70% perchloric acid, added for protein precipitation. Supernatants were collected and protein clean-up was performed using Oasis HLB µelution well plates. Eluted proteins were dried and resuspended with A phase before LCMS analysis.
Data source location	IRMB, Montpellier hospital, France
Data accessibility	Data is with article