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. 2018 Jun 11;18:37. doi: 10.1186/s12911-018-0606-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Complex formation in the free-diffusion model from the antibody-free simulations. The number of CD28 and CTLA-4 molecules bound to B7–1 and B7–2 at the immunological synapse, during the antibody-free simulations (a). The dynamic changes in the total numbers of CTLA-4/B7 complex, CD28/B7 complex, amount of CTLA-4 at the intra-cellular environment and the total number of CTLA-4 monomers are provided (b)