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. 2018 Jun 11;18:37. doi: 10.1186/s12911-018-0606-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The dose-curves for the blocking of B7 ligands to CTLA-4 by ipilimumab (a) and tremelimumab (b) in the simulations performed in either of the B7 -knock-out model, where either of the B7 ligands and CD28 were removed. The complex formation of CTLA-4/B7–1 and CTLA-4/B7–2 in the absence of CD28 and antibody is also simulated (c)