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. 2018 Jun 11;18:37. doi: 10.1186/s12911-018-0606-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Antibody-mediated changes in the complex formation at the synapse in the free-diffusion model: The dynamic changes in the different complexes, such as CTLA-4/antibody, CTLA-4/B7 ligands and CD28/B7 ligands, at the synapse are simulated at 10 μM and 15 μM of antibodies, ipilimumab (a, c) and tremelimumab (b, d)