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. 2018 Jun 11;18:37. doi: 10.1186/s12911-018-0606-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Sensitivity of the interactions towards the perturbations in the association (k_on) and dissociation (k_off) rate constants for CTLA-4/Tremelimumab complex. The changes in the numbers of CTLA-4/Tremelimumab complex (a), CTLA-4/B7–1 complex (b), CTLA-4/B7–2 complex (c), CD28/B7–1 complex (d), and CD28/B7–2 complex (e) in response to the perturbations are shown