Table 1.
Deletions | Duplications | |||||||
---|---|---|---|---|---|---|---|---|
Chromosomal arm | 4q | 9q | 13q | 15q | 18q | 7p | 7q | 11q |
TCGA: OD II + III | 9.8% | 4.5% | 10.5% | 9.0% | 15.0% | 6.0% | 9.0% | 4.5% |
TCGA: OD III | 13.8% | 5.2% | 10.3% | 12.1% | 20.7% | 6.9% | 10.3% | 6.9% |
POLA: OD III | 16.2% | 14.7% | 5.9% | 14.7% | 8.8% | 4.4% | 7.3% | 19.1% |
Chromosomal arms affected by deletions (4q, 9q, 13q, 15q and 18q) and duplications (7p, 7q and 11q) in subsets of oligodendrogliomas in addition to the characteristic 1p/19q co-deletion. Percentages of affected oligodendrogliomas are shown for the TCGA cohort (TCGA: OD II + III comprised 133 oligodendrogliomas of WHO grades II and III, TCGA: OD III comprised 58 oligodendrogliomas of WHO grade III) and the POLA cohort [33] (POLA: OD III comprised 68 oligodendrogliomas of WHO grade III)