Table 5.

Administration guidelines for infusion recommencement after infusion-related reactions[22]

Grade	Management of IRR
Grades 1-2 (mild to moderate)	Once reaction symptoms resolve, the infusion should be resumed at no more than half the rate at which the IRR occurred
	If the patient does not experience any further IRR symptoms, infusion rate escalation may be resumed at increments and intervals as appropriate up to the maximum rate of 200 mL/h
Grade 3 (severe)	Once reaction symptoms resolve, consider restarting the infusion at no more than half the rate at which the reaction occurred
	If the patient does not experience additional symptoms, infusion rate escalation may be resumed at increments and intervals as appropriate
	The procedure above should be repeated in the event of recurrence of Grade 3 symptoms. Permanently discontinue daratumumab upon the third occurrence of a Grade 3 or greater infusion reaction
Grade 4 (life-threatening)	Permanently discontinue daratumumab treatment

IRR: Infusion-related reaction