Table 2.

Description of the presence virulence traits in GAS genomes of the study.

Virulence trait	MUMCMC2276	MUMCMC661	MUMCMC650	MUMCMC317	MUMCMC1953	MUMCMC2034	MUMCMC261	MUMCMC616	MUMCMC662	MUMCMC51	MUMCMC13	MUMCMC433	Gene(s) with potential for conferring virulence traits
Antiphagocytic M protein	+	+	+	+	+	+	+	+	+	+	+	+	emm, ennX, fbp, igaR
Streptokinase	+	+	+	+	+	+	+	+	+	+	+	+	ska
CAMP factor	+	+	+	+	+	+	+	+	+	+	+	+	cfa
Streptolysin O	+	+	+	+	+	+	+	+	+	+	+	+	slo
Streptolysin S	+	+	+	+	+	+	+	+	+	+	+	+	sagB, C, D, E, F, H, I, asn-ORF, ABC transporter
Putative peptidoglycan hydrolase	+	+	+	+	+	+	+	+	+	+	+	+	GbpB/SagA/PcsB
Hyaluronate lyase precursor	+	+	+	+	+	+	+	+	+	+	+	+	hyl
Hyaluronan synthase	–	+	+	+	+	+	+	+	+	+	+	+	hasA
Exotoxin*	+	+	+	+	+	+	+	–	–	–	–	–	Scarlet fever
Streptococcal pyrogenic exotoxin A*	–	–	–	–	+	–	–	+	+	+	+	–	speA
Cysteine Protease B*	+	+	+	+	+	+	+	+	+	+	+	+	speB
Streptococcal pyrogenic exotoxin C*	+	+	+	+	+	+	+	+	+	+	+	+	speC
Streptococcal pyrogenic exotoxin G	+	+	+	+	+	+	+	+	+	+	+	+	speG
Streptococcal pyrogenic exotoxin H*	–	+	–	–	+	–	–	–	–	–	–	–	speH
Streptococcal pyrogenic exotoxin I*	–	+	–	–	–	–	–	–	–	–	–	–	speI
Streptococcal pyrogenic exotoxin J	–	–	–	–	+	–	+	+	+	+	+	–	speJ
Streptococcal pyrogenic exotoxin K*	–	–	–	–	–	–	–	–	–	–	–	+	speK
Streptococcal pyrogenic exotoxin L*	–	–	–	–	–	–	–	–	–	–	–	–	speL
Streptococcal pyrogenic exotoxin M*	–	–	–	–	–	–	–	–	–	–	–	–	speM
Streptococcal mitogenic exotoxin Z	+	+	+	+	+	+	+	+	+	+	+	–	smeZ
C5a peptidase	+	+	+	+	+	+	+	+	+	+	+	+	scpA
Secreted endo-beta-Nacetylglucosaminidase	+	+	+	+	+	+	+	+	+	+	+	+	ndoS
Streptococcal inhibitor of complement	_	–	–	–	–	–	–	+	+	+	+	+	sic
Exotoxin nucleases	–	–	–	–	–	–	–	–	–	–	–	–	spd1, 2, 3, 4, sda
Immunoglobulin-binding protease	+	+	+	+	+	+	+	+	+	+	+	+	ideS
Collagen-like surface proteins	+	+	+	+	+	+	+	+	+	+	+	+	sclA, B