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. 2018 Apr 25;15(6):5231–5242. doi: 10.3892/etm.2018.6097

Figure 4.

Figure 4.

Cellular signaling in response to pretreatment of ARVMs with rhSLPI, subjected to ischemia/reperfusion. ARVMs were treated with 200, 400, 600, 800 and 1,000 ng/ml rhSLPI for 2 h prior to sI. The phosphorylation of (A) p38 MAPK and (B) Akt was determined by western blot analysis. Each bar graph represents the phosphorylation ratio (p-/t-) of p38 MAPK and Akt. *P<0.05 vs. control group; #P<0.05 vs. sI group. ARVM, adult rat ventricular myocytes; rhSLPI, recombinant human secretory leukocyte protease inhibitor; sI, stimulated ischemia; MAPK, mitogen-activated protein kinase; p-phosphorylated; t-, total.