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. Author manuscript; available in PMC: 2018 Jun 12.
Published in final edited form as: Bioconjug Chem. 2015 May 15;26(6):1021–1031. doi: 10.1021/acs.bioconjchem.5b00044

Scheme 4.

Scheme 4

Delivery of camptothecin to cancer cells. PC liposomes doped with 1 were reacted with azido-camptothecin 20 to produce 21 through click chemistry. The liposomes were then incubated with cancer cells to deliver camptothecin (22) through ester hydrolysis within cells.