Table 2.
Logistic regression analysis and genotype frequency of polymorphisms in IL-1α gene between HCC and control.
| SNP locus | HWE | Genotype | HCC | Control | Model | OR (95% CI) | P-value |
|---|---|---|---|---|---|---|---|
| n=178 | n=397 | ||||||
| rs3783550 Intron |
0.51 | C/C | 67 (53.2%) | 186 (50.1%) | Codominant | 0.81 (0.55–1.21) | 0.31 |
| A/C | 51 (40.5%) | 157 (42.3%) | Dominant | 0.86 (0.52–1.43) | 0.56 | ||
| A/A | 8 (6.3%) | 28 (7.5%) | Recessive | 0.51 (0.19–1.38) | 0.18 | ||
| rs17561 missense (Ser114Ala) |
0.68 | G/G | 163 (92.6%) | 350 (88.2%) | Codominant | 0.50 (0.24–1.06) | 0.06 |
| T/G | 13 (7.4%) | 45 (11.3%) | Dominant | 0.52 (0.24–1.14) | 0.10 | ||
| T/T | 0 (0.0%) | 2 (0.5%) | Recessive | 0.00 (0.00–NA) | 0.11 | ||
| rs1800587 5′-UTR |
0.12 | C/C | 162 (91.5%) | 349 (87.9%) | Codominant | 0.70 (0.35–1.39) | 0.30 |
| T/C | 14 (7.9%) | 45 (11.3%) | Dominant | 0.66 (0.31–1.39) | 0.27 | ||
| T/T | 1 (0.6%) | 3 (0.8%) | Recessive | 0.87 (0.06–12.77) | 0.92 | ||
| rs1800794 5′-nearGene |
0.23 | C/C | 158 (91.9%) | 350 (88.6%) | Codominant | 0.69 (0.34–1.39) | 0.29 |
| T/C | 13 (7.6%) | 43 (10.9%) | Dominant | 0.64 (0.30–1.39) | 0.25 | ||
| T/T | 1 (0.6%) | 2 (0.5%) | Recessive | 0.94 (0.06–14.63) | 0.97 |
HWE is Hardy-Weinberg equilibrium. Genotype distributions are shown as number (%). Odds ratio (OR), 95% confidence interval (CI), and p-values were from logistic regression analysis with codominant, dominant, and recessive models controlling age and gender as covariates. SNP is single nucleotide polymorphism. Total number of each SNP is different, because genotypes of some SNPs are unreadable.