Fig. 4.

SCI growth inhibiting effect. (a) BLM and ${\mathrm{AlPcS}}_{2\mathrm{a}}+\mathrm{BLM}+\mathrm{FUS}$ (SCI) treated spheroids using $0.2\mathrm{W}{\mathrm{cm}}^{-2}$ FUS sonication exposure for 3 min and $1\text{-}\mu \mathrm{g}/\mathrm{mL}$ ${\mathrm{AlPcS}}_{2\mathrm{a}}$. (b) SDT and SCI (BLM concentration of $0.5\mu \mathrm{g}/\mathrm{ml}$). (c) Effects of FUS on BLM efficacy in the absence and presence of sonosensitizers, BLM concentration of $0.5\mu \mathrm{g}/\mathrm{ml}$. Each data point represents spheroid volume after 2 weeks in culture as a percent of untreated controls and is the mean of three experiments. Error bars denote standard errors. Asterisks (*) denote significant differences ($p<0.05$) compared to control values.