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. 2018 Apr 25;9:282. doi: 10.3389/fneur.2018.00282

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Copyright © 2018 Li, Zhao, Pan, Ru, Zuo, Qu, Liao, Chen, Ruan and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genetic inhibition of nexilin impedes oligodendrocyte progenitor cell migration and remyelination after SAH. (A) Western blot analysis of nexilin and GAPDH in white matter (WM) at 3 days after SAH. The statistics histograms are shown on the right, n = 3 for each group. (B) Representative images of NG2/nexilin- and NG2/Olig2-positive cells and the myelin ultrastructure at 3 days after SAH are shown. (C) Statistics of double-positive NG2 and Olig2 cells in WM of mouse brains at 3 days after SAH, n = 3 for each group. (D) G-ratios representing the myelin thickness based on the TEM images, n ≥ 60 for each group. (E) Statistical histogram of the axon diameter (micrometer) of myelin based on the TEM images, n ≥ 60 for each group. The data are presented as the mean ± SEM; ***P < 0.001 versus the sham group, ^#P < 0.05 versus SAH + scramble siRNA group, ^##P < 0.01 versus SAH + scramble siRNA group, n.s. indicates no significance. SAH, subarachnoid hemorrhage.

Genetic inhibition of nexilin impedes oligodendrocyte progenitor cell migration and remyelination after SAH. (A) Western blot analysis of nexilin and GAPDH in white matter (WM) at 3 days after SAH. The statistics histograms are shown on the right, n = 3 for each group. (B) Representative images of NG2/nexilin- and NG2/Olig2-positive cells and the myelin ultrastructure at 3 days after SAH are shown. (C) Statistics of double-positive NG2 and Olig2 cells in WM of mouse brains at 3 days after SAH, n = 3 for each group. (D) G-ratios representing the myelin thickness based on the TEM images, n ≥ 60 for each group. (E) Statistical histogram of the axon diameter (micrometer) of myelin based on the TEM images, n ≥ 60 for each group. The data are presented as the mean ± SEM; ***P < 0.001 versus the sham group, ^#P < 0.05 versus SAH + scramble siRNA group, ^##P < 0.01 versus SAH + scramble siRNA group, n.s. indicates no significance. SAH, subarachnoid hemorrhage.