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. 2018 Apr 25;9:282. doi: 10.3389/fneur.2018.00282

Figure 8.

Figure 8

Schematic diagram of the present study. After subarachnoid hemorrhage (SAH), elevated nexilin levels facilitate F-actin rearrangement and then promote oligodendrocyte progenitor cell (OPC) migration and remyelination. Nexilin expression is negatively regulated by the activated thrombin receptor protease-activated receptor 1 (PAR1) on the OPC membrane, which is followed by the activation of downstream Ras-proximate-1 (RAP1) and the promotion of RAP1 phosphorylation. The suppression of PAR1 by thrombin receptor antagonist peptide (TRAP) inhibits PAR1 signaling but enhances nexilin and promotes OPC migration and remyelination after SAH.