Table 1.
Plasma levels of epinephrine, NE, DA, HVA, serotonin, 5-HIAA, and melatonin in vitiligo patients compared with control subjects.
| Variables | Control group (n = 40) |
Vitiligo group (n = 60) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SVP |
AVP |
|||||||||||
| Male (n = 15) | Female (n = 25) | Total (n = 40) | Male (n = 10) | Female (n = 15) | Total (n = 25) | Male (n = 15) | Female (n = 20) | Total (n = 35) | ||||
| Epinephrine (pmol/L) | 350 ± 3.5 | 301.6 ± 2.08 | 319.7 ± 4.17 | 396.2 ± 3.77 | 379.2 ± 1.32 (NS) | 386 ± 2.37*** | 647.7 ± 2.89 | 588 ± 4.62 | 613.5 ± 5.83***, ### | |||
| Norepinephrine (nmol/L) | 2157 ± 23.22 | 1920 ± 21.59 | 2009 ± 24.26 | 2385 ± 31.53 | 2288 ± 12.16 (NS) | 2327 ± 17.20*** | 3007 ± 23.60 | 2718 ± 16.01 | 2842 ± 27.94***, ### | |||
| Dopamine (pmol/L) | 208.6 ± 2.17 | 179.6 ± 1.70 | 190.5 ± 2.60 | 528.1 ± 4.55 | 496.1 ± 8.34 | 508.9 ± 6.14*** | 570.5 ± 3.01 | 504.3 ± 4.65a | 532.7 ± 6.33***, ## | |||
| HVA (ng/mL) | 9.73 ± 0.39 | 7.92 ± 0.27 (NS) | 8.60 ± 0.26 | 24.10 ± 0.60 | 21.93 ± 0.56 (NS) | 22.80 ± 0.46*** | 31.27 ± 1.21 | 25.05 ± 1.02a | 27.71 ± 0.93***, ### | |||
| Serotonin (ng/mL) | 24.93 ± 0.73 | 34.16 ± 0.75 | 30.70 ± 0.89 | 55.10 ± 1.21 | 64.93 ± 0.94 | 61.0 ± 1.22*** | 74.53 ± 1.61 | 83.65 ± 1.15 | 79.74 ± 1.21***, ### | |||
| 5-HIAA (ng/mL) | 4.33 ± 0.15 | 6.0 ± 0.26 (NS) | 5.37 ± 0.21 | 8.30 ± 0.51 | 9.80 ± 0.48 (NS) | 9.20 ± 0.83*** | 10.60 ± 0.51a | 12.30 ± 0.31 (NS) | 11.57 ± 0.31***, ### | |||
| Melatonin (ng/mL) | 1.46 ± 0.08 | 2.46 ± 0.05 (NS) | 2.09 ± 0.08 | 4.90 ± 0.23 | 6.86 ± 0.44 | 6.08 ± 0.34*** | 7.0 ± 0.32 | 8.65 ± 0.43 | 7.94 ± 0.31***, ### | |||
Values expressed as mean ± SEM; ***p < 0.001 and means a significant difference between SVP or AVP groups and control group while ##p < 0.01 and ###p < 0.001 and means a significant difference between AVP and SVP group (Total vs. Total; between groups).
aMeans a non-significant difference between AVP and SVP (Total vs. Total; Male vs. Male; Female vs. Female, between groups).
NS means a non-significant difference within groups (Male vs. Female).
SVP, stable vitiligo patients; AVP, active vitiligo patient; HVA, homo-vanillic acid; 5-HIAA, 5-hydroxyindolacetic acid; NE, norepinephrine; DA, dopamine.