Table 2.
Serum levels of fT3, fT4, TSH, estradiol, testosterone, prolactin, cortisol, and ACTH in vitiligo patients compared with control subjects.
| Variables | Control group (n = 40) |
Vitiligo group (n = 60) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| SVP |
AVP |
||||||||
| Male (n = 15) | Female (n = 25) | Total (n = 40) | Male (n = 10) | Female (n = 15) | Total (n = 25) | Male (n = 15) | Female (n = 20) | Total (n = 35) | |
| fT3 (pmol/L) | 5.38 ± 0.08 | 4.45 ± 0.06 | 4.80 ± 0.08 | 2.45 ± 0.09 | 1.46 ± 0.06 | 1.86 ± 0.11*** | 2.07 ± 0.04b | 1.17 ± 0.02b | 1.56 ± 0.08b, *** |
| fT4 (pmol/L) | 24.67 ± 0.76 | 20.36 ± 0.36 | 21.98 ± 0.48 | 7.55 ± 0.62 | 6.03 ± 0.06 (NS) | 6.64 ± 0.28*** | 6.20 ± 0.07b | 4.16 ± 0.14b (NS) | 5.03 ± 0.19b *** |
| TSH (mIU/L) | 3.98 ± 0.07 | 4.5 ± 0.06 | 4.30 ± 0.06 | 5.97 ± 0.11 | 6.93 ± 0.10 | 6.54 ± 0.12*** | 7.06 ± 0.07 | 7.96 ± 0.06 | 7.57 ± 0.09***, ### |
| Estradiol (pmol/L) | 106.7 ± 1.94 | 1250 ± 4.54 | 821.5 ± 88.71 | 124.8 ± 1.10a | 1302 ± 8.11a | 831.1 ± 117.8a | 165.1 ± 1.06a,b | 2103 ± 32.83 | 1272 ± 165.5b, * |
| Testosterone (nmol/L) | 25.2 ± 0.79 | 1.54 ± 0.04 | 10.42 ± 1.85 | 9.90 ± 0.52 | 2.06 ± 0.20a | 5.20 ± 0.81* | 2.49 ± 0.03 | 0.98 ± 0.04a,b (NS) | 1.62 ± 0.13b*** |
| Prolactin (μg/L) | 7.95 ± 0.32 | 20.76 ± 0.59 | 15.96 ± 1.06 | 22.4 ± 0.65 | 34.53 ± 0.68 (NS) | 29.68 ± 1.30*** | 42.67 ± 0.74 | 85.15 ± 1.23 | 66.94 ± 3.68***, ### |
| Cortisol (nmol/L) | 250.4 ± 0.88 | 454.2 ± 2.29 | 377.8 ± 15.87 | 311 ± 4.33a | 473 ± 3.89a | 408.2 ± 16.45a | 710.3 ± 5.82 | 865.8 ± 4.69 | 799.1 ± 13.67***, ### |
| ACTH (pmol/L) | 7.92 ± 0.21 | 5.0 ± 0.22 | 6.10 ± 0.27 | 4.65 ± 0.17 | 2.42 ± 0.06 | 3.31 ± 0.23*** | 2.82 ± 0.03 | 1.53 ± 0.05b | 2.08 ± 0.11***, ### |
Values expressed as mean ± SEM.
*p < 0.05, ***p < 0.001 and means a significant difference between SVP or AVP groups and control group while ###p < 0.001, means a significant difference between AVP and SVP groups (Total vs. Total; between groups).
aMeans a non-significant difference between SVP or AVP group and control group.
bMeans a non-significant difference and AVP and SVP (Total vs. Total; Male vs. Male; Female vs. Female, between groups).
NS means a non-significant difference within groups (Male vs. Female).
SVP, stable vitiligo patient; AVP, active vitiligo patient; fT3, free triiodothyronine; fT4, free thyroxine; TSH, thyroid-stimulating hormone; ACTH, adrenocorticotrophic hormone.