Unilateral dialysis of 1.0 mM (n=7) muscimol (filled circles) during the day significantly increased ventilation (V̇I, panel A, P =0.025) and breathing frequency (f panel B, P =0.044) but did not alter tidal volume (VT, panel C, P =0.196) compared to dialysis of mCSF alone (open circles) (n=7). Data are means ± SE. The solid lines indicate the period during which muscimol was dialyzed (60-120 minutes). Two-way repeated measures ANOVA was used (dose and time as factors) to obtain F and P values. Asterisks denote values significantly different between open and closed symbols (P < 0.05, post hoc test).