Table 2.
Parameters reflecting function of 11β-HSD1, 11β-HSD2, 5α, and 5β-reductases as well as the overall glucocorticoid balance in the body
| Controls | PE | GH | CH | |
|---|---|---|---|---|
| Function of 11β-HSD2 | ||||
| UFF/UFE | 0.277 (0.198–0.373) | 0.1693 (0.115–0.221) | 0.2062 (0.158–0.261) | 0.282 (0.207–0.421) |
| Function of 11β-HSD1 | ||||
| THFstot/THEstot | 0.280 (0.235–0.337) | 0.3461 (0.256–0.445) | 0.318 (0.247–0.373) | 0.271 (0.228–0.385) |
| THFfree/THEfree | 0.498 (0.353–0.720) | 0.416* (0.268–0.601) | 0.476 (0.347–0.606) | 0.428 (0.264–0.597) |
| Function of 5α and 5β-reductases | ||||
| alloTHFtot/Ftot | 0.0477 (0.0248–0.0805) | 0.0661 (0.0264–0.1354) | 0.0489 (0.0282–0.0916) | 0.0391* (0.0178–0.0487) |
| THFtot/Ftot | 2.20 (1.63–3.38) | 3.513 (2.15–6.11) | 3.222 (2.25–4.59) | 3.19* (1.85–4.48) |
| alloTHFtot/THFtot | 0.0203 (0.0133–0.0329) | 0.0179 (0.0096–0.0249) | 0.0151* (0.0070–0.0330) | 0.01062 (0.0074–0.0183) |
| Overall glucocorticoid balance in the body | ||||
| Plasma F/E | 4.79 (3.66–5.76) | 3.003 (2.57–4.21) | 4.01* (3.53–5.26) | 4.94 (3.44–6.07) |
| Urinary Ftot/Etot | 1.14 (0.86–1.30) | 1.08 (0.86–1.31) | 1.04 (0.92–1.26) | 1.11 (0.89–1.43) |
| THFstot + THEstot [µg/mmol Cr] | 380.1 (292.4–504.5) | 394.2 (253.8–659.7) | 489.71 (346.6–699.3) | 450.3 (302.8–623.5) |
| THFstot/UFF | 16.80 (11.50–25.64) | 36.953 (23.04–85.05) | 33.073 (18.62–45.22) | 23.78* (13.96–37.59) |
| (THFstot + THEstot)/UFF | 76.39 (52.28–117.21) |
140.633 (91.93–322.45) | 138.193 (81.07–178.36) | 109.81* (66.52–155.77) |
| (THFstot + THEstot)/(UFF + UFE) | 15.42 (11.39–23.51) | 19.471 (13.95–35.80) | 23.581 (14.67–33.12) | 22.58 (12.52–35.30) |
| Steroid conjugation with glucuronides and sulphates | ||||
| F conjugation degree [%] | 85.0 (81.2–89.5) | 90.93 (87.1–94.2) | 88.91 (85.2–91.4) | 87.1 (76.3–91.6) |
| E conjugation degree [%] | 44.2 (31.3–53.8) | 42.6 (33.7–47.9) | 42.3 (31.2–49.1) | 39.0 (30.2–52.1) |
| THF conjugation degree [%] | 98.8 (98.3–99.0) | 99.01 (98.6–99.2) | 99.01 (98.6–99.2) | 98.8 (98.6–99.0) |
| THE conjugation degree [%] | 99.3 (99.0–99.5) | 99.2 (98.8–99.4) | 99.3 (99.0–99.5) | 99.2 (98.4–99.4) |
Results are presented as medians (interquartile range) for groups of women with preeclampsia (PE), gestational hypertension (GH), chronic hypertension (CH) and normotensive controls
*close to be significant (p < 0.09)
1p < 0.05; 2p < 0.005; 3p < 0.001