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. 2018 Jun 8;13:3397–3409. doi: 10.2147/IJN.S167383

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© 2018 Buduru et al. This work is published and licensed by Dove Medical Press Limited

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siRNA therapeutic implication.

Notes: (A) Some relevant examples of nanosystems used for siRNA application, comprising a great variety of viral/nonviral delivery systems, some of which are used in oral cancer: lipid nanoparticles, nanorods, peptides, dendrimers, PEG nanoparticles, or adeno-associated viruses with application in oral cancer. (B) Schematic view of siRNA mechanism. siRNAs can have an endogenous origin, being transcribed from the genome and processed by Dicer or it can be delivered by artificial nanosystems. Both the exogenous and the endogenous siRNAs are loaded in the RISC complex, with the help of which only the guide strand is kept for further interaction with its corresponding mRNA.

Abbreviations: dsRNA, double-stranded RNA; mRNA, messenger RNA; OSCC, oral squamous cell carcinoma; PEG, polyethylene glycol; RISC, RNA-induced silencing complex; siRNA, small interfering RNA.