Figure 1.

Depression-like behaviors in PRS mice are reversed by treatment with genipin. Forty-day-old NS (offspring of non-stressed dams) and PRS (offspring of prenatally stressed dams) male mice were treated i.p. once a day for 7 days, with vehicle (VEH), 25 mg/kg of genipin (GEP). The depression-like behaviors were measured 2 h after the last treatment by means of FST (A) and TST (B). Administration of genipin at the dose above normalizes locomotor (horizontal and vertical) hyperactivity in PRS but not NS mice (C and D). The data are expressed as mean +/- SEM of 10 mice per group. The indices for TST and FST are represented as seconds, while locomotor activities are expressed as counts during 15 min. # P < 0.05 when genipin (GEP)-treated PRS mice are compared to vehicle (VEH)-treated PRS mice *P < 0.05 when PRS mice are compared to vehicle (VEH)- and genipin (GEP)-treated NS mice.