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. 2018 May 10;13(3):318–330. doi: 10.1080/15592294.2018.1451720

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Figure 1. — Reduced DNA methylation in hypothalamus is associated with AMC. (A) Principal components 1 and 2 of the average DNA methylation in 20 kb windows with masking of CpG Islands separately groups AMC samples (red outline, n = 3) from control samples (blue outline, n = 3). Outlines represent 95% confidence intervals. (B) Average genome wide CpG methylation is significantly reduced (P = 0.015) by 3.12% in AMC samples (n = 3) compared with control samples (n = 3). (C) DNA hypomethylation in the AMC hypothalami at PND9 was significant (*P < 0.05) on every chromosome except chromosome 13 and X (P < 0.52 and 0.054, respectively). RM ANOVA AMC group X-chromosome interaction F (20.80) = 21.89, P < 0.0001; * Benjamini-Hochberg corrected t-tests for each chromosome all P < 0.05.