Skip to main content
. Author manuscript; available in PMC: 2018 Jun 12.
Published in final edited form as: Cell Host Microbe. 2017 Apr 12;21(4):507–517.e5. doi: 10.1016/j.chom.2017.03.007

Figure 7. BET inhibitors drive HSV-1 viral reactivation from latency in vivo.

Figure 7

(A) Latently infected mice were injected twice daily with JQ1+ or control vehicle and mRNA levels of viral lytic genes (ICP27, gC) and control GAPDH were determined at 24 and 48 h post injection. (B) Latently infected mice were injected with JQ1+ or control JQ1− and mRNA levels of viral lytic genes (ICP27, gC) are shown at the indicated times post injection. (A–B) Data are means +/− s.e.m., n = 3 pools of 5 ganglia per group. (C) Viral DNA at 48 h post injection in eyes of latently infected mice injected with vehicle or JQ1+. Data are means +/− s.e.m., n = 8. (A–C) Viral mRNA or DNA levels in samples were normalized based on the levels of cellular GAPDH mRNA or DNA respectively. *p < 0.05; **p < 0.01.