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. 2013 Nov 15;1(1):2–9. doi: 10.1002/ams2.10

Figure 4.

figure

Changes in circulating alanine aminotransferase ALT, nucleosomes, and high mobility group box 1(HMGB1), after lipopolysaccharide (LPS) injection. Plasma levels of ALT, nucleosomes, and HMGB1 were measured 3 h after LPS (8 mg/kg) injection. As cell death usually becomes evident several hours after the insult, significant increases were recognized in nucleosomes and HMGB1 but not in ALT. Therefore, the increases are thought to be mainly from the result of cell death by neutrophil extracellular traps (NETosis). Original data.