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. 2014 Apr 23;1(3):127–134. doi: 10.1002/ams2.38

Figure 3.

figure

A. Total cytochrome P450 (CYP) contents in the microsomal fraction of kidney grafts 3 h after reperfusion. Total CYP content at 3 h after kidney transplants were significantly decreased in kidney grafts preserved in control UW solution for 24 h. In contrast, kidney grafts stored with carbon monoxide (CO) (soluble CO levels approximately 40 μM) maintained a nearly normal concentration of CYP at the same time point. Data are shown as mean ± standard deviation. *P < 0.05 versus control UW. B. Western blots for typical CYPs CYP1A2 and CYP2E1. Treatment with CO markedly prevented CYP degradation. Representative results are shown from two independent experiments using four samples.