. Author manuscript; available in PMC: 2019 Feb 7.

Published in final edited form as: Hum Genet. 2018 Feb 7;137(2):183–193. doi: 10.1007/s00439-018-1871-6

Table 4.

Comparison of mosaic variants in CHD trios and controls

Parameter	Cases (n = 669)	#/Sample	Controls (n = 416)	#/Sample	p value
Deleterious CADD C score	23	0.034	14	0.034	0.560
High heart expression [HHE] genes	17	0.025	5	0.013	0.339
Deleterious CADD C + HHE	7	0.010	3	0.007	1.000
Missense	23	0.034	13	0.031	0.696
Nonsense/splice	5	0.007	3	0.007	1.000
Synonymous	17	0.025	7	0.016	0.817
Intronic	47	0.070	28	0.067	0.345
Regulatory	33	0.049	12	0.029	0.364