Table 2.
Prevalence of beta (β)-HPV DNA detected on the surface of all EGL cases and the normal genital skin of EGL cases and controls, at the time of lesion detection (index visit), 6, and 12 months prior to lesion detection
| HPV species/type | Controls n=134 |
Any EGLa n=67 |
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| Normal genital skin | Normal genital skin | EGL | |||||
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| 12mo prior | 6mo prior | Index visit | 12mo prior | 6mo prior | Index visit | Index visit | |
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| No. (%) | No. (%) | No. (%) | No. (%) | No. (%) | No. (%) | No. (%) | |
| Any β-HPV type | 113 (84.3) | 117 (87.3) | 111 (82.8) | 58 (86.6) | 57 (85.1) | 54 (80.6) | 43 (64.2) |
| β1 | |||||||
| Any β1 | 88 (67.2) | 86 (64.2) | 87 (65.4) | 48 (71.6) | 44 (67.7) | 42 (68.9) | 34 (50.7) |
| HPV5 | 35 (26.7) | 35 (26.1) | 30 (22.6) | 21 (31.3) | 21 (32.3) | 18 (29.5) | 11 (16.4) |
| HPV8 | 27 (20.6) | 23 (17.2) | 23 (17.3) | 9 (13.4) | 10 (15.4) | 11 (18.0) | 6 (9.0) |
| HPV12 | 21 (16.0) | 20 (14.9) | 25 (18.8) | 18 (26.9) | 17 (26.2) | 15 (24.6) | 8 (11.9) |
| HPV14 | 9 (6.9) | 9 (6.7) | 9 (6.8) | 10 (14.9) | 10 (15.4) | 8 (13.1) | 7 (10.4) |
| HPV19 | 1 (0.8) | 1 (0.7) | 0 (0) | 1 (1.5) | 1 (1.5) | 1 (1.6) | 0 (0) |
| HPV20 | 0 (0) | 2 (1.5) | 4 (3.0) | 2 (3.0) | 4 (6.2) | 6 (9.8) | 3 (4.5) |
| HPV21 | 5 (3.8) | 12 (9.0) | 14 (10.5) | 8 (11.9) | 7 (10.8) | 4 (6.6) | 6 (9.0) |
| HPV24 | 35 (26.7) | 28 (20.9) | 37 (27.8) | 15 (22.4) | 17 (26.2) | 17 (27.9) | 4 (6.0) |
| HPV25 | 2 (1.5) | 1 (0.7) | 3 (2.3) | 1 (1.5) | 0 (0) | 0 (0) | 0 (0) |
| HPV36 | 17 (13) | 17 (12.7) | 13 (9.8) | 6 (9.0) | 8 (12.3) | 7 (11.5) | 5 (7.5) |
| HPV47 | 42 (32.1) | 39 (29.1) | 35 (26.3) | 6 (9.0) | 7 (10.8) | 19 (31.1) | 4 (6.0) |
| HPV93 | 2 (1.5) | 1 (0.7) | 5 (3.8) | 1 (1.5) | 2 (3.1) | 0 (0) | 1 (1.5) |
| β2 | |||||||
| Any β2 | 68 (51.9) | 69 (51.5) | 71 (53.4) | 49 (73.1) | 47 (72.3) | 32 (52.5) | 24 (35.8) |
| HPV9 | 13 (9.9) | 16 (11.9) | 10 (7.5) | 8 (11.9) | 3 (4.6) | 6 (9.8) | 5 (7.5) |
| HPV15 | 11 (8.4) | 9 (6.7) | 6 (4.5) | 6 (9.0) | 10 (15.4) | 6 (9.8) | 2 (3.0) |
| HPV17 | 16 (12.2) | 18 (13.4) | 16 (12.0) | 15 (22.4) | 19 (29.2) | 13 (21.3) | 8 (11.9) |
| HPV22 | 21 (16.0) | 22 (16.4) | 30 (22.6) | 14 (20.9) | 19 (29.2) | 13 (21.3) | 7 (10.4) |
| HPV23 | 23 (17.6) | 20 (14.9) | 22 (16.5) | 21 (31.3) | 14 (21.5) | 11 (18.0) | 5 (7.5) |
| HPV37 | 10 (7.6) | 12 (9.0) | 9 (6.8) | 8 (11.9) | 2 (3.1) | 3 (4.9) | 1 (1.5) |
| HPV38 | 24 (18.3) | 26 (19.4) | 26 (19.5) | 21 (31.3) | 25 (38.5) | 11 (18.0) | 12 (17.9) |
| HPV80 | 6 (4.6) | 16 (11.9) | 8 (6.0) | 12 (17.9) | 12 (18.5) | 5 (8.2) | 6 (9.0) |
| β3 | |||||||
| Any β3 | 7 (5.3) | 7 (5.2) | 5 (3.8) | 11 (16.4) | 16 (24.6) | 6 (9.8) | 3 (4.5) |
| HPV49 | 4 (3.1) | 3 (2.2) | 3 (2.3) | 5 (7.5) | 8 (12.3) | 2 (3.3) | 1 (1.5) |
| HPV75 | 3 (2.3) | 4 (3.0) | 1 (0.8) | 8 (11.9) | 8 (12.3) | 3 (4.9) | 3 (4.5) |
| HPV76 | 1 (0.8) | 1 (0.7) | 2 (1.5) | 5 (7.5) | 2 (3.1) | 2 (3.3) | 0 (0) |
| β4 | |||||||
| HPV92 | 3 (2.3) | 5 (3.7) | 4 (3.0) | 3 (4.5) | 4 (6.2) | 3 (4.9) | 1 (1.5) |
| β5 | |||||||
| HPV96 | 9 (6.9) | 9 (6.7) | 10 (7.5) | 8 (11.9) | 7 (10.8) | 2 (3.3) | 5 (7.5) |
| Multiple β-HPV types | |||||||
| ≥2 types | 77 (57.5) | 78 (58.2) | 79 (59.0) | 47 (70.1) | 45 (67.2) | 35 (52.2) | 26 (38.8) |
Note: Sample sizes change depending on specimen availability and validity of HPV results.
a
Includes all pathologically confirmed external genital lesions (EGLs).