Table 3.
Prevalence of beta (β)-HPV DNA and alpha (α)-HPV DNA detected on the surface of condyloma cases and the normal genital skin of condyloma cases and controls, at the time of lesion detection (index visit), 6, and 12 months prior to lesion detection
| HPV species/type | Controls n=86 |
Condyloma/Suggestive of Condyloma n=43 |
|||||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| Normal genital skin | Normal genital skin | Condyloma | |||||
|
|
|
|
|||||
| 12mo prior | 6mo prior | Index visit | 12mo prior | 6mo prior | Index visit | Index visit | |
|
|
|
|
|||||
| No. (%) | No. (%) | No. (%) | No. (%) | No. (%) | No. (%) | No. (%) | |
| Any β-HPV type | 73 (84.9) | 75 (87.2) | 72 (83.7) | 37 (86.0) | 36 (83.7) | 33 (76.7) | 28 (65.1) |
| β1 | |||||||
| Any β1 | 53 (63.1) | 52 (60.5) | 56 (65.1) | 30 (69.8) | 26 (61.9) | 27 (69.2) | 23 (53.5) |
| HPV5 | 21 (25.0) | 21 (24.4) | 22 (25.6) | 14 (32.6) | 13 (31.0) | 11 (28.2) | 7 (16.3) |
| HPV8 | 15 (17.9) | 13 (15.1) | 12 (14.0) | 5 (11.6) | 5 (11.9) | 7 (17.9) | 5 (11.6) |
| HPV12 | 11 (13.1) | 11 (12.8) | 14 (16.3) | 10 (23.3) | 9 (21.4) | 9 (23.1) | 4 (9.3) |
| HPV14 | 6 (7.1) | 4 (4.7) | 4 (4.7) | 5 (11.6) | 7 (16.7) | 7 (17.9) | 7 (16.3) |
| HPV19 | 1 (1.2) | 1 (1.2) | 0 (0) | 1 (2.3) | 1 (2.4) | 1 (2.6) | 0 (0) |
| HPV20 | 0 (0) | 1 (1.2) | 4 (4.7) | 0 (0) | 1 (2.4) | 3 (7.7) | 2 (4.7) |
| HPV21 | 3 (3.6) | 6 (7.0) | 10 (11.6) | 6 (14.0) | 5 (11.9) | 2 (5.1) | 2 (4.7) |
| HPV24 | 19 (22.6) | 18 (20.9) | 23 (26.7) | 6 (14.0) | 9 (21.4) | 9 (23.1) | 3 (7.0) |
| HPV25 | 0 (0) | 0 (0) | 1 (1.2) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| HPV36 | 13 (15.5) | 9 (10.5) | 9 (10.5) | 4 (9.3) | 5 (11.9) | 6 (15.4) | 3 (7.0) |
| HPV47 | 24 (28.6) | 23 (26.7) | 20 (23.3) | 4 (9.3) | 5 (11.9) | 13 (33.3) | 3 (7.0) |
| HPV93 | 1 (1.2) | 0 (0) | 2 (2.3) | 0 (0) | 1 (2.4) | 0 (0) | 0 (0) |
| β2 | |||||||
| Any β2 | 45 (53.6) | 47 (54.7) | 50 (58.1) | 29 (67.4) | 29 (69.0) | 21 (53.8) | 17 (39.5) |
| HPV9 | 9 (10.7) | 12 (14.0) | 6 (7.0) | 2 (4.7) | 1 (2.4) | 4 (10.3) | 2 (4.7) |
| HPV15 | 8 (9.5) | 8 (9.3) | 5 (5.8) | 5 (11.6) | 7 (16.7) | 5 (12.8) | 2 (4.7) |
| HPV17 | 11 (13.1) | 11 (12.8) | 12 (14.0) | 8 (18.6) | 11 (26.2) | 9 (23.1) | 5 (11.6) |
| HPV22 | 13 (15.5) | 14 (16.3) | 21 (24.4) | 9 (20.9) | 13 (31.0) | 10 (25.6) | 4 (9.3) |
| HPV23 | 15 (17.9) | 11 (12.8) | 14 (16.3) | 13 (30.2) | 8 (19.0) | 8 (20.5) | 4 (9.3) |
| HPV37 | 9 (10.7) | 11 (12.8) | 8 (9.3) | 4 (9.3) | 1 (2.4) | 1 (2.6) | 0 (0) |
| HPV38 | 18 (21.4) | 21 (24.4) | 21 (24.4) | 13 (30.2) | 19 (45.2) | 8 (20.5) | 8 (18.6) |
| HPV80 | 3 (3.6) | 12 (14.0) | 4 (4.7) | 8 (18.6) | 9 (21.4) | 3 (7.7) | 4 (9.3) |
| β3 | |||||||
| Any β3 | 4 (4.8) | 5 (5.8) | 4 (4.7) | 4 (9.3) | 11 (26.2) | 5 (12.8) | 1 (2.3) |
| HPV49 | 2 (2.4) | 2 (2.3) | 2 (2.3) | 2 (4.7) | 5 (11.9) | 2 (5.1) | 0 (0) |
| HPV75 | 1 (1.2) | 3 (3.5) | 1 (1.2) | 3 (7.0) | 5 (11.9) | 3 (7.7) | 1 (2.3) |
| HPV76 | 1 (1.2) | 1 (1.2) | 2 (2.3) | 1 (2.3) | 1 (2.4) | 1 (2.6) | 0 (0) |
| β4 | |||||||
| HPV92 | 1 (1.2) | 3 (3.5) | 2 (2.3) | 1 (2.3) | 2 (4.8) | 1 (2.6) | 1 (2.3) |
| β5 | |||||||
| HPV96 | 7 (8.3) | 8 (9.3) | 7 (8.1) | 3 (7.0) | 4 (9.5) | 1 (2.6) | 2 (4.7) |
| Multiple β-HPV types | |||||||
| ≥2 types | 49 (57.0) | 50 (58.1) | 52 (60.5) | 28 (65.1) | 28 (65.1) | 25 (58.1) | 18 (41.9) |
| α-HPV typea | |||||||
| HPV6/11 | 2 (2.3) | 2 (2.3) | 4 (4.7) | 16 (37.2) | 16 (37.2) | 18 (41.9) | 26 (60.5) |
Note: Sample sizes change depending on specimen availability and validity of HPV results.
a
Surface of normal genital skin and EGL specimens were evaluated for α-HPV using Linear Array.