Table 2. Organ Pharmacokinetic Parameters of Gemcitabine (GEM) and Its Inactive Metabolite 2′,2′-Difluorodeoxyuridine (dFdU) after Single Intravenous Injection of Free GEM and mPEG-b-PCC-g-GEM-g-DC (Abbreviated as F-GEM and P-GEM) at GEM Equivalent Dose of 40 mg/kg in NSG Mice Bearing Orthotopic Pancreatic Tumors.
| pharmacokinetic parameters | ||||
|---|---|---|---|---|
|
| ||||
| organs | samples | t1/2 (h) | Cmax (ng/mL) | AUC (ng/mL × h) |
| liver | F-GEM | 4.5 ± 0.3 | 43,406 ± 6249 | 347,329 ± 26,578 |
| P-GEM | 12.6 ± 0.9 | 31,598 ± 2636 | 564,977 ± 37,638 | |
| heart | F-GEM | 9.3 ± 0.7 | 3,879 ± 113 | 38,237 ± 3,494 |
| P-GEM | 11.7 ± 0.4 | 3,449 ± 129 | 121,475 ± 1,378 | |
| spleen | F-GEM | 8.2 ± 0.5 | 25,635 ± 1204 | 20,5084 ± 9,533 |
| P-GEM | 8.7 ± 0.3 | 25,366 ± 5435 | 59,3119 ± 8,122 | |
| lung | F-GEM | 10.3 ± 0.8 | 4,593 ± 395 | 80,216 ± 1,378 |
| P-GEM | 14.4 ± 1.7 | 3,720 ± 264 | 131,612 ± 6,115 | |
| tumor | F-GEM | 7.8 ± 0.05 | 3,009 ± 125 | 79,970 ± 7,715 |
| P-GEM | 8.5 ± 0.4 | 9,765 ± 1025 | 263,251 ± 9,148 | |
| kidney | F-GEM | 9.6 ± 0.3 | 6,811 ± 497 | 102,983 ± 6,557 |
| P-GEM | 11.8 ± 1.1 | 4,069 ± 226 | 105,975 ± 5,451 | |